CORRECTING and REPLACING Synergy Pharmaceuticals to Present at Upcoming September Investor Conferences

NEW YORK–(BUSINESS WIRE)– In the release dated September 6, 2017, the presentation date and time
for the Cantor Fitzgerald Global Healthcare Conference should be changed
to Wednesday, September 27, 2017 at 9:45 a.m. Eastern Time (instead of
Monday, September 25, 2017 at 10:20 a.m. Eastern Time).

The corrected release reads:

SYNERGY PHARMACEUTICALS TO PRESENT AT UPCOMING SEPTEMBER INVESTOR
CONFERENCES

Synergy Pharmaceuticals Inc. (NASDAQ: SGYP) today announced that the
company will present corporate updates at three upcoming investor
conferences in New York City during September:

Rodman & Renshaw 19^th Annual Global Investment Conference
on Monday, September 11, 2017 at 9:35 a.m. Eastern Time.

Ladenburg Thalmann 2017 Healthcare Conference on Tuesday, September 26,
2017 at 10:30 a.m. Eastern Time.

Cantor Fitzgerald Global Healthcare Conference on Wednesday, September
27, 2017 at 9:45 a.m. Eastern Time.

A live webcast of the presentations will be accessible through the
Investor Relations section of the company’s website at www.synergypharma.com.
A replay of the webcast will be available on Synergy’s website for 90
days following each conference.

About Synergy Pharmaceuticals Inc.

Synergy is a biopharmaceutical company focused on the development and
commercialization of novel gastrointestinal (GI) therapies. The company
has pioneered discovery, research and development efforts on analogs of
uroguanylin, a naturally occurring and endogenous human GI peptide, for
the treatment of GI diseases and disorders. Synergy’s proprietary GI
platform includes one commercial product TRULANCE™ (plecanatide) and a
second lead product candidate, dolcanatide. For more information, please
visit www.synergypharma.com.

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